Telomeres are specialized nucleoprotein complexes that protect the ends of eukaryotic chromosomes. These highly repetitive entities are progressively depleted after each round of DNA replication in all dividing human somatic cells. The loss of telomeric DNA is replenished by the action telomere maintenance mechanisms. Because most normal human somatic tissues do not possess a constitutive means to fully maintain their telomeres, actively dividing cells demonstrate gradual telomeric length reduction with each cell division hence telomere shortening acts as a biological clock that is related with organismal ageing. When a single, or a few, critically short telomeres occur, DNA damage responses are activated, and cells undergo growth arrest. At the crossroads of DNA damage repair and genomic instability, telomere research has significantly expanded our knowledge on fundamental mechanisms involved in natural biological ageing and age-related diseases including cancer initiation and progression, cardiovascular disease, autoimmune diseases, neurodegeneration and COVID associated morbidities. The rapidly emerging telomere-based diagnostics and genome stability assays are expected to exert broad applications not only in every day’s clinical practice but also in the highly thriving fields of assisted reproduction and rejuvenating medicine. In the proposed action, Gagos lab in the Biomedical Research Foundation of the Academy of Athens Greece (BRFAA) based in its high expertise and on in-house state-of-the-art equipment can immediately provide unique super sensitive and highly accurate diagnostic assays on telomere length and functionality, genome integrity and instability with a plethora of applications in personalized precision medicine.